Last Updated on October 17, 2025
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What if the key to improving your gut and skin health isn't just probiotics or diet, but a colostrum-based immunoglobulin supplement toxin binder that specifically targets unfriendly gut bugs and their toxins that are messing up your gut?
You probably know that colostrum is a huge trend, but its capacity is far more limited compared to an immunoglobulin supplement (especially IgG).
So what then are immunoglobulins?
Immunoglobulins are a superstar toxin binder that also supports gut barrier repair, and helps to calm inflammation — without interfering with or binding to food, medications, or your good gut bugs.
I’ve seen amazing shifts using the immunoglobulin supplement HistaGut Relief in my clinical practice, especially in clients with chronic skin rashes who felt stuck and reactive to nearly every food they ate.
Joining me to discuss how this colostrum supplement called immunoglobulins binds to toxins like LPS and C. difficile, helps repair leaky gut, and acts in a superior way compared to colostrum is Brian Kaufman. Brian is the Vice President of Global Business Development for Proliant Health & Biologicals, an American bio-pharmaceutical company committed to global health through the production of plasma proteins for use in diagnostics, cell culture, and dietary supplement applications.
A decorated Army veteran and GI Nurse, Brian has over 15 years of experience in direct patient care and medical sales, where his primary focus has been in digestive health and infectious disease.
This episode will change how you think about gut health. Let’s dive in!
Or, listen on your favorite app: iTunes (Apple Podcasts) | Spotify | Stitcher | TuneIn | Subscribe on Android
In This Episode:
- What are immunoglobulins (how do they act as a gut toxin binder)?
- What makes IgG so potent and important?
- Colostrum benefits & problems no one talks about with colostrum supplement
- Immunoglobulins (like IgG) vs. a colostrum supplement
- Specific inflammatory toxins made in your gut (and the best gut toxin binder to use)
- How THIS immunoglobulin supplement lowers your gut toxin burden
- Connection between gut inflammation & immune burnout
Quotes
“If you're getting recurrent skin rashes and things like that, that is literally your body's check engine light for: You’ve got something wrong with your gut. It may manifest as something topical on your skin, but it began as an inflammatory reaction in your microbiome.”
“Immunoglobulins are your body's innate and acquired security system.”
“LPS makes up 60% of the endotoxin in the gut microbiome.”
Links
Find Brian on LinkedIn
Healthy Skin Show ep. 194: Immunoglobulins + Histamine Problems: A Game Changer? w/ Kiran Krishnan
402: Harnessing A Gut Toxin Binder For Gut Health (How THIS Dairy-Free Colostrum Immunoglobulin Supplement Can Massively Help) w/ Brian Kaufmann {FULL TRANSCRIPT}
Jen nifer Fugo (00:17.346)
Brian, it is such an honor to have you here today on the Healthy Skin Show to talk about my favorite immunoglobulin supplement, the hidden gut toxin burden most people don’t talk about and more.
Brian Kaufman (00:21.888)
Thank you so much for having me, Jennifer. I appreciate the opportunity. Anytime that I can take a little bit of time and kind of be the microbiome nerd that I am, I'm going to step on that soapbox.
Jennifer Fugo (00:33.014)
Yeah, I love nerding out on the microbiome, as I know many of my listeners and those who are watching us and tuning in through the video love talking about this.
Jennifer Fugo (02:54.229)
I want to talk about this whole thing with colostrum versus ImmunoLin (colostrum benefits vs immunoglobulin supplement). And ImmunoLin is something that you're well-versed in, a lot of people might recognize that name, but it's actually immunoglobulins. And immunoglobulins are really important for gut health. And so I thought, let's start off just doing a little bit of an immunoglobulins 101. What exactly are they?
Brian Kaufman (03:30.443)
Good question. So, immunoglobulins are your body's innate and acquired security system. It's their job that when you come in contact with invaders from the outside, whether that be some type of a bacterial antigen, or mold, or fungi, or something like that, it's their job to recognize it, develop an immunologic response so that it can combat it the next time it comes in contact. The problem with that is that your body only makes about five grams of immunoglobulin every day. And if you're immunosuppressed, if you're post some type of antibiotics use, or maybe you're just feeling down or you're feeling sick, you're gonna deplete that five grams of IgG very, very quickly. And that's why there's been such a rise in supplementing with immunoglobulin supplement. (1) Give your immune system some help.
I think about it like, a lot of people love Taylor Swift, right? But if you see pictures of her out in the wild, she's got a team of security members that are watching her back all the time. That team is your immunoglobulins. They're there to protect you. And there's just not enough of them right now in this post-modern and ironic world, with hyperprocessed foods.
Jennifer Fugo (04:43.873)
Yeah.
Brian Kaufman (04:56.498)
And we're not, our own acquired immune system isn't as robust as maybe our parents’ were. And so that is why you need that. And that is why ImmunoLin, and specifically immunoglobulins, are the missing piece to the gut health puzzle.
Jennifer Fugo (05:01.165)
Now, can I just ask you a quick question? I have always been under the impression that immunoglobulins are present in a lot of what I guess we would call the mucosal membrane areas of the body. I mean, obviously the gut, there's a lot of mucosa there. But I am also thinking of like, the nose, the mouth, like anywhere where we have an entry point, so to speak. Is that accurate to say that they really would be throughout the whole entire, kind of, like gateway microbiomes all the way down? Or is it, do you know if it's just more concentrated to certain parts of the GI tract?
Brian Kaufman (05:37.705)
It's definitely more concentrated in the gut microbiome because you have so much exposure, but it starts, like ingestion, it starts right here in your mouth, right? And so IgA and amylase, which is an enzyme that's secreted in your salivary glands, helps to kind of break down food, and IgA starting that immunologic response. But once you get into the gut, that's where IgG, which is the most robust and the most polyclonal, which means it fights against more things and binds to more antigens, that's where the real war zone is, right? And that's why IgG shines. And that's why, in my opinion, IgG is the most important immunoglobulin that your body makes, and it's also the most important one for you to supplement with an immunoglobulin supplement.
Jennifer Fugo (06:23.105)
So this brings up a good question, because I'm thinking to myself, somebody might be like, IgA, IgG? Maybe somebody's seen IgM. What are those?
Brian Kaufman (06:37.088)
So there's specific antibodies that your body develops as part of your innate immune system, so what you're born with, and then your acquired immune system, what you react to and generate more. Each one of those immunoglobulins does one thing. It seeks out, binds, and removes specific inflammatory pathogens, whether they be bacterial, whether that be die-off from probiotic use, or even in our foods, or even in the air. And so that's their whole job.
But they do serve slightly different functions. IgA is a little bit more respiratory-related and in your saliva. IgM is a little bit smaller amount, that has some specific needs and uses. But again, IgG is the most important one. It's the largest, it's the most robust, it's the one that is leading the fight against the bad guys.
Jennifer Fugo (07:26.997)
And so that IgG is an immunoglobulin.
Brian Kaufman (07:31.284)
Yep, immunoglobulin G. You may also hear the word antibody. So same thing, different word.
Jennifer Fugo (07:38.51)
Interesting. So I know, too, that some immunoglobulins can be found in colostrum supplement, which is huge right now.
Brian Kaufman (07:47.507)
It is.
Jennifer Fugo (08:08.076)
We were just talking beforehand about how creatine now, all of a sudden, is in its heyday, and colostrum is also in its heyday. It's all the rage. And so how, what's the deal with colostrum or a colostrum supplement and immunoglobulins? Like, are they the same, are they different? And how are they different, if they are?
Brian Kaufman (08:08.254)
Very different, very different. Now again, all antibodies, or immunoglobulins, do the same thing, but the source matters. And so, essentially, you've got three major players in the immunoglobulin game. The first one is colostrum. Colostrum's been around for, gosh, 100 years. It's that first milking, it's a high IgG component, but it does come from milk, and naturally 30% of the world's population cannot handle dairy, lactose, and things like that. So there are some limitations there. Also, the way that it's harvested, it's not a very consistent system. So if you're looking for a colostrum product, you may notice like, okay, well, this is a 10% IgG, this one's a 20% IgG, this one doesn't have an IgG spec on it at all. That's because there's so much variability in it.
The reason why it's such a rage, and colostrum, I want to make sure that I preface this, colostrum, and IgY specifically, can be great tools in your gut health toolbox, but they're molecularly inferior to a serum-based IgG like you get with ImmunoLin. So as an example, colostrum, at best, you're getting about a 20% IgG. A serum-based IgG like ImmunoLin is going to have over 50% IgG, so over double the amount. Then you look at the protein content. Colostrum is about 50% protein for the good stuff, the not-so-good stuff in the 20% range. A serum-based IgG, like ImmunoLin, is over 92% protein. That means it's an isolate. It's so, so clean. And that clean part of the protein matters because if it's clean like that, that means there's no endotoxin, which is literally the thing we're trying to get rid of by supplementing with an antibody.
So you're gonna have double the protein, double the IgG, none of the lactose and none of the endotoxin. Just a very clean, consistent, high IgG product that is also more polyclonal. The source also matters in what that antibody is able to bind onto. I mentioned IgY, that's hyper-immunized egg immunoglobulins. I would say if you had to rank them, ImmunoLin, serum-based IgG, that's the top, that's number one. Then you've got colostrum, and then you've got IgY. All are great tools in your gut health toolbox, but a serum-based IgG is gonna be molecularly superior. I use this example a lot when I'm talking to patients, is I'll say, yeah, you can absolutely get where you're going with colostrum or IgY, but it's like trying to drive across the country in a golf cart. You'll get there, maybe. Maybe, but wouldn't you rather just get in your car, take a plane?
Jennifer Fugo (10:58.987)
Yeah, yeah. One of my biggest concerns with colostrum, obviously there's the issue of obviously a dairy allergy, like an outright dairy allergy as well, which I don't believe, correct, there's not a dairy allergy issue with ImmunoLin?
Brian Kaufman (11:18.016)
There's not.
Jennifer Fugo (11:26.695)
So just doing the bovine serum immunoglobulins. So that's one nice thing. And then also,
I find the fact that you, a lot of times, can, so, I mean, I just want everybody to think about this for a second. If you were to take two grams of each substance, the amount of immunoglobulins available in colostrum, what you're saying, is literally a fraction of what's available in the same amount. So if you're really looking at even just the potency, I would argue as a clinical nutritionist that from a potency standpoint, from what it's just able to do, and also, I mean, let's be honest, supplements cost money. Like, if I'm taking something, I want to make sure that it's actually working. To me, I would rather take an immunoglobulin supplement that has more capability to do more work than a smaller fraction of work. That's just from my standpoint. But I just kind of think immunoglobulins, and what I've seen in my clinic and how they work, I just think immunoglobulins, if they're available to you, depending on where you live, I think that they're just a better option if you have a choice.
Brian Kaufman (12:30.504)
Well, I mean, I ask people all the time, why would you pay more for an inferior product that also has lactose and endotoxin in it? And I'm not just talking, just saying that, we actually did clinical trials on this where we took the top four selling colostrum products on the market. And we did this twice. We did it in 2017 and we repeated it again last year. (2)
Jennifer Fugo (12:42.103)
Yeah.
Brian Kaufman (12:58.78)
So to say, because more people are looking, okay, I needed immunoglobulins. And then they get down the rabbit hole and go, oh, well, a serum-based IgG seems to be a lot better. It's cleaner, there's no endotoxin, there's no lactose, and it's got double the protein, double the IgG, and it's not as expensive. Why would I choose the inferior product?
Jennifer Fugo (13:24.877)
Yeah. And you mentioned the word endotoxin, and I don't know if everybody's going to know what that is, but it's a really, really big deal in terms of the gut. So, can you give us an understanding of what are endotoxins, and how do they play out and impact the gut? And then maybe we can go even further beyond the gut.
Brian Kaufman (13:51.713)
Sure. So endotoxin, you're going to hear the words endotoxin and antigen used a lot together. They're the same thing. It's just an umbrella term for outside agents that cause inflammation, usually bacteria, fungi, or mold.
Jennifer Fugo (14:09.279)
And so when you're inside, when you're inside the gut, right? Like, let's pretend we just hit a little button, shrink ourselves down, like I'm thinking, Honey, I Shrunk the Kids.
Brian Kaufman (14:19.018)
Yep. Or like Magic School Bus.
Jennifer Fugo (14:38.731)
Right, we're like, inside the gut and we're looking around. I think most people tend to think of toxins as something that is in the environment, right? So, outside of the body. And while yes, there is truth to that, there are toxins all around us, what is probably most overlooked is the toxin production that happens within the GI tract. So how does that happen? And then that creates something called endotoxemia. So I just wanna kind of give people this better sense of what's happening within the gut that they might not see, because they might eat stuff, right, I'm like, I eat beans, and sometimes I react to them, and sometimes I don't. I eat this, that, and the other, and I can't make heads or tails of why I feel sick sometimes, but not all the time. There's no consistency. And then they get stuck thinking that they just can't eat any foods, or they're not sure. They're so uncertain of why they don't feel well at random times, and I think this will be really helpful for people to understand this particular concept.
Brian Kaufman (15:30.228)
Absolutely. So the microbiome is such a diverse environment. It's like downtown Beijing at rush hour traffic. There's so much going on, right? And as an example, there's more E. coli in your colon, right now, than there are number of people who have ever lived, ever.
Jennifer Fugo (15:54.157)
Ever!
Brian Kaufman (15:57.621)
You truly are what you eat, and more so the bacteria in your gut and how it interacts with them truly shifts your mood, how you look, how you feel, all of those things. There's so much going on. Absolutely, there are endotoxin issues outside of the body, in our air, and our food, and our water, and things like that. But there's also a symphony of bacterial growth, and proliferation, and die-off all going on at the same time in our gut. And you'll hear a lot of people talk about diversity. That's just a fancy word for saying the ratio of good bacteria, or commensal bacteria, versus bad bacteria, or antigens and endotoxins. And when the bad guys outweigh the good guys, what you're going to get is a high level of inflammation that breaks down the gut barrier. Your gut barrier is like this, it's protecting you all the time, right? Those dendritic cells reach out from there, grab something it wants or push something out it doesn't want.
But when as a human, when you're dealing with a lot of inflammation, it's almost like being on a hamster wheel. You're running, running, running, running, but you just can't get off. And when that happens, that inflammation slowly breaks down that barrier. And next thing you know, you’ve got this swiss cheese gut barrier that’s just letting good guys and bad guys in all the time. And your immune system is just exhausted. It's like, okay, this is bad, this is good, I don't know what to do, and it’s constantly sending off inflammatory cytokines, which are messenger cells, to say, hey, we’ve got bad stuff here. And so I always call it a symphony because there's so much going on. And you know when the music is bad, when the diversity of the bad guys is high, and when the music is good, and that's when you're living your best life, your skin looks good, you're sleeping well, you've got a good appetite. A lot of people don't realize having a good appetite is a sign of good health.
Jennifer Fugo (17:56.043)
So somebody who may wake up and, all throughout the day, is pretty much not hungry, like at all, so they're forcing themselves to eat. That could also be a sign that there is actually some type of imbalance under the surface.
Brian Kaufman (18:10.77)
Absolutely, their immune system is literally holding on for dear life. Your brain's releasing cortisol and everything like that to protect you. So you're going to go the whole day without eating and have no appetite, that's one of the first signs. When I do food diaries with patients and stuff and say, give me an idea of what you eat on a daily basis throughout an entire week. And as soon as I start seeing like, I don't eat until one o'clock or two o'clock, I'm like, gut barrier dysfunction. You've got dysbiosis, we’ve got to fix that.
Jennifer Fugo (18:39.781)
Can I ask too, because you mentioned E. coli, and from my understanding E. coli, because they're gram-negative bacteria, have the capacity to actually, they like to create a lot of these lovely lipopolysaccharides, or LPS, and those, if I'm correct, are considered endotoxins, yes?
Brian Kaufman (19:05.12)
Absolutely. They're the, if E. coli is Gru from Despicable Me, LPS are the minions, and they're everywhere. In fact, LPS makes up 60% of the endotoxin in the gut microbiome. And so it's one that we concentrate a lot to try to eradicate. And one of the great things about a serum-based IgG like ImmunoLin is that it specifically targets and binds LPS. (3,4,5)
Now, here's how all this works. So for everyone listening, I want you to picture a Sunday volleyball, sand volleyball game with the family. Think of that net, picture it in your head, think of that net as your gut microbiome. And now take a ping pong ball. That's the engine, that's LPS. Now if you throw that ping pong ball at the volleyball net and it's a broken down gut barrier, it's just gonna go straight through, right, continuously setting off that inflammatory response. However, when you introduce a serum-based immunoglobulin, like ImmunoLin, it's gonna specifically target out that antigen, that ping pong ball, it's gonna bind onto it. And when it binds onto it, it's gonna increase and change its overall size so that it's simply too big to flow through that damaged gut layer. So now that ping pong ball turns into a volleyball. Now throw that volleyball up against that net, what's gonna happen? It's gonna come right back. Now, fewer foreign antigens setting off the inflammatory response allows the immune system to go, whew, all right, we’ve got less of these bad guys in here. We can start sending out anti-inflammatory messages to the immune system to start to cool down that gut layer and start to regenerate healthy new tissue at that damaged gut layer, and then take this and slowly turn it into a nice, good gut barrier. (3,4,5)
Jennifer Fugo (20:57.175)
So with that being said, because it sounds like what you're talking about is almost like there's a toxin binder capacity to immunoglobulins. And one question that I am oftentimes asked is like, okay, some people understand that binders might look like activated charcoal, right? There are things that you cannot take around medications, other food, other supplements, because they will literally suck it all up, and now whatever you actually needed that for, you're not gonna get access to it. So is that the same as this kind of binding capacity that you're describing with the immunoglobulins or immunoglobulin supplement?
Brian Kaufman (21:36.939)
Completely opposite. So, absolutely right, so charcoal binders, they grab everything. They're gonna grab your breakfast, they're gonna grab the Tylenol you took a couple hours ago, they're gonna grab any kind of medication. It may even negatively interact with some of the medications and foods that you're already taking. Because some of that is food for your commensal bacteria, your good bacteria. However, a serum-based IgG is painted with the acquired immune system of the donor, which would be a bovine source, and is non-systemic, meaning it doesn't move into the bloodstream, and it's non-reactive to food, drugs, or other commensal bacteria. (1) It's gonna literally, let's say this is your IgG and this is your breakfast.
Jennifer Fugo (22:20.737)
Yeah, you've got a pen in a bottle. Exactly.
Brian Kaufman (22:25.734)
Yep, it's gonna go oh, oh, nope, sorry, toast, we don't want you. We're gonna go over here and grab this LPS over here.
Jennifer Fugo (22:31.309)
So it's a lot different. What it sounds like you're saying is it's looking for specific toxins, instead of just randomly and blindly binding to whatever is present in the GI tract.
Brian Kaufman (22:47.168)
Absolutely.
Jennifer Fugo (22:50.783)
So would that mean that you could take an immunoglobulin supplement with food, like at the same time, or with other supplements?
Brian Kaufman (22:56.096)
Absolutely. In fact, I encourage patients to take it with food for a couple of reasons. Number one, when you're ingesting food, that's when you're using your hands and things like that, that's when you're going to open up yourself to the most exposure to inflammatory bacteria to begin with. Also, compliance. If you know, I take my IgG with breakfast every day, you're going to be more compliant, more consistent. And that way, if you're more consistent with that and arming your microbiome, then you're going to get the results that you want faster.
This also kind of delves into why a serum-based IgG is a better option over colostrum and IgY. IgY binds to about seven to 10 different antigens in the gut, colostrum binds to about 18 to 20, whereas a serum-based IgG like ImmunoLin binds on to over 40 different antigens. So not only are you grabbing that LPS, you're grabbing E. coli, Listeria. (3,4,5) I'll tell you my own aha moment as a GI nurse, C. diff particles A and B.
Jennifer Fugo (24:00.234)
Really? Wow!
Brian Kaufman (24:02.432)
And if you're listening right now and you don't know, yes, absolutely. That was my aha moment. Yeah, I managed quite a few patients at the Medical College of Georgia with serum IgG before it was available over the counter as a dietary supplement. And my aha moment was, hey, this specifically binds C. diff particles A and B. We're gonna use this here. (3,4,5) Because it's such an immunosuppressed disease state. And now I can diagnose C. diff from three floors away, right? But also these patients, they're stuck in their room, they're on contact precautions, so they can't have any family members or anyone come to see them. When a nurse like me or a doc comes in, they look like Darth Vader. They got all their universal precautions on, gown, glove, masks, everything like that.
And it's not only debilitating to the immune system, but also your mental health, because you're just sitting in that room alone. But yeah, so it also binds to C. diff particles A and B. (3,4,5) And that was, again, my aha moment, like, okay, this is for real, I got to get involved in this. And I actually called ProLiant Health & Biologicals and said, I want to know what your next clinical trial is, how can I get involved?
Jennifer Fugo (25:14.1)
So if it can bind to the toxins, because that's actually a really interesting question, because I came to realize, this was not something I was taught in school, but I realized that, so, for many people who don't realize, they kind of know that you can get really sick from certain antibiotics like vancomycin and whatnot, it can trigger a whole problem. So it's not uncommon, unfortunately, if you're in the hospital and you get given, say vancomycin, you could end up with a C. diff infection. And everybody's like, how could you get an infection from taking an antibiotic? Isn't the antibiotic supposed to kill the bacteria, and now all of sudden you have an infection from the antibiotic? And I'm like, no, the C. diff was already there. That's the problem, you already had it.
So, what if you're, for many of us, unless you're doing, say, like a type of stool testing that would even look for C. diff, the A toxin, B toxin, whatever, if you don't know, is it then helpful, just regardless if you happen to be one of those people that might have some C. diff hanging around in your GI tract, right? It's just hanging out, it's not necessarily in this full blown infection state, is it possible at that point in time for immunoglobulins to help? Like is it helping to kind of shuttle, or create a difference in the balance between those organisms, or is it just sopping up the toxins? I'm just trying to understand how this could be helpful in ways that I think the audience could appreciate.
Brian Kaufman (26:44.874)
Absolutely. So let's talk about antibiotics first. Antibiotics, amazing invention by modern medicine, right?
Jennifer Fugo (26:49.057)
Agreed.
Brian Kaufman (26:52.094)
But everything that has positives also has some negatives. That antibiotic is going to completely kill whatever bacteria you've got in your gut, depending on what antibiotic it is, what bacteria or antigen that you're trying to eradicate. But it's not specific like an immunoglobulin. It's also going to kill all the good bacteria and all the commensal bacteria that are kind of keeping that C. diff particle at bay in a normal standpoint. So, antibiotic comes into the body, kills the bad bacteria, also kills the good bacteria, and then you're just sitting there completely vulnerable to this inactive C. diff particle, or some other bacterial antigen, that then starts to completely flourish.
And that's why, when you see a lot of people with leaky gut and you start kind of doing history and physical, yeah, you know, I did a round of antibiotics about six months ago and I just haven't been the same since. Well, that's because you've been, your microbiome completely got decimated, and then, because you were vulnerable, you then came in contact with more bacterial antigens, and you're on that hamster wheel of low-grade inflammation. The gut barrier that looked like this, now looks like this, and just can't get any relief from this constant low-grade inflammation to heal back. The key difference, the missing piece to that puzzle, is adding an antibody. I work with tons of gastroenterologists, infectious disease doctors, internal medicine doctors, and they know, if they're gonna start like a broad-spectrum antibiotic, they start on serum IgG, an ImmunoLin product, first, to kind of prepare the microbiome for this onslaught of whatever they're gonna give.
Jennifer Fugo (28:34.55)
So if somebody, like I have clients that, I can't even say, they get on and off antibiotics because of recurrent staph infections on their skin. They're really in this state where it's just like recurrent skin infections, over and over again. And it does take a lot to kind of break that cycle, but it is possible, I have seen it in my practice. So in that type of person, would this be maybe a helpful, what you're saying makes a lot of sense. Like we don't know what can be lurking under the surface, and when we go and disrupt the balance, right? So, we need antibiotics, they have good, because I really want people to understand that I think we've done a disservice in the integrative space of demonizing all antibiotics. Because there's a time and a place for them, and sometimes the natural stuff is just not gonna cut it in and of itself, right?
Brian Kaufman (29:28.032)
Absolutely.
Jennifer Fugo (29:29.088)
If somebody's got a really bad systemic infection, we don't want them to end up hospitalized and need IV antibiotics. But if somebody is on these recurrent rounds of antibiotics, it sounds like immunoglobulins, which also, I assume, antibiotics, quote unquote, can't kill, right, because they're not alive. I think that's the other thing, people go, oh my gosh, I can't take this with antibiotics because it's like a probiotic.
Brian Kaufman (29:53.192)
Yeah.
Jennifer Fugo (29:58.785)
And I'm like, it's not. But it could be supportive of helping to kind of sop up and bind, so you're saying to the toxins, but also potentially to certain types of organisms, is that correct?
Brian Kaufman (30:07.818)
Yep, so gram-positive, gram-negative bacteria, flagella, the very thing that moves them around, and things like that. We've all been watching some type of like cop drama movie or something like that, and you see the bad guy getting away and they're shooting at the car and you're like, shoot the tires out, shoot the tires out. Serum IgG shoots the tires out, because it also binds to the flagella, the very thing that's moving it through the microbiome.(3,4,5)
Jennifer Fugo (30:28.46)
So these can be really helpful, and they're not contraindicated with, say, somebody taking antibiotics, or maybe even, what about people who are on more heavy duty medications, like things that are like biologic drugs, or even immunosuppressants? Like is there any concern for those individuals with immunoglobulins?
Brian Kaufman (30:55.248)
One of the great things about serum IgG is it's got over 45 human clinical trials.
Jennifer Fugo (31:07.857)
Oh, wow, so there's a lot of data here.
Brian Kaufman (31:11.628)
Oh, tons, yeah. This product was available by prescription only until I launched it in a lower dosing strategy back in 2018. It was only available by prescription. And I literally looked at our leadership and I said, guys, this is nothing more than a hearty, dense, rich, isolate protein with a high immunoglobulin content. There's no contraindications, there's no drug or food interactions. It's non-systemic, which means it acts locally in the GI tract only and is not absorbed in the bloodstream. I'll give you an example. We've done about six trials in IBD. (1) And in those trials, we did some where there was no biologic or corticosteroid therapy, and then we did some where it was added in addition.
For those that it was added in addition, they were able to not only reduce flares and GI distress and things like that, but they were able to lower the dosage of those biologic drugs at a shorter pace, have less hospitalizations, and also spend less money on other drugs. (6)
Jennifer Fugo (32:04.246)
Wow.
Brian Kaufman (32:11.504)
In fact, serum IgG is like a biologic for the gut, because biologics do one thing, they block a specific type of inflammation that's causing you your problem. It's just happening in the gut (6) rather than in the bloodstream, like with the biologic.
Jennifer Fugo (32:24.202)
Yeah. Well, I mean, I have used it so much in practice over the last several years and found it to be so helpful. I got converted as a fan a while ago, and I honestly haven't looked back. And it's something that I've shared with a lot of even conventional doctors, especially dermatologists who've come on the Healthy Skin Show, because I do think that there's such a benefit to using them, especially in people who have chronic skin issues, because obviously there's a huge connection between the gut and skin. We know that through the gut-skin axis, and there's plenty of research at this point in time to know that one impacts the other.
So I just want to remind everybody too, that we have the immunoglobulins available in quellshop.com, the product is called HistaGut Relief IgG. So we took the time to really take these really beautiful, I don't know, they're like little tiny, like they suck things up. I don't want to call them binders, but I like how you're describing them. They're almost like little Pacmans that help go around and support the body to be calmer, to have less of these inflammatory things and just calm down. And I've seen so many really interesting experiences with clients who have actually been able to reintroduce foods that they truly thought was like a severe food intolerance, which they actually didn't have. It was what was going on in the GI tract that was causing so much reactivity. So it was just so fascinating to see how these play out in real human beings. And yeah, I'm excited for what's ahead because I know that there's more and more research being done on these. So any final thoughts, Brian, that you want to add for somebody who's gotten through all of this and gone, wow, this is like mind blowing.
Brian Kaufman (34:13.588)
Yep, absolutely. So the first thing is, when people think of gut health, the first thing they think of is probiotics. And guess what? Me too. Probiotics are absolutely fantastic. And there's varying sources of probiotics, I like spores personally. But whether it's probiotics, or enzymes, or botanicals like slippery elm and marshmallow, things like that, or even things like inositol, glucosamine. All of those things feed good bacteria, except enzymes which break down food. But all those things just feed the good guys, but they don't do anything to the bad guys, which is the underlying cause of intestinal inflammation and dysbiosis, which is what leads to abdominal pain, bloating, flatulence, diarrhea, and also poor skin. I always tell patients, if you're getting recurrent skin rashes and things like that, that is literally your body's check engine light for, you got something wrong with your gut.
Jennifer Fugo (35:14.826)
Yeah, because there's always something there, yeah.
Brian Kaufman (35:22.093)
It may manifest as something topical on your skin, but it began as an inflammatory reaction in your microbiome.
Jennifer Fugo (35:27.008)
Yeah, and we see that, too, with so many autoimmune diseases. I think that link has been really hammered home over the last 15 years, with different thyroid issues, different, even anxiety and depression. We start to see when people are just struggling and they're not themselves, there tends to be, when you actually look in the research, there's a link between what's going on within the gut and what's happening with these symptoms in other parts of the body. So to say that we just cut the body into pieces and address just that no longer makes sense anymore. And I know that many of the listeners want to try and look at their body as a whole and find the way back towards better thriving health, which I appreciate, and I know you do too.
Brian Kaufman (36:08.884)
Yep, I do too. So let's talk about protocol. Probiotics, enzymes, all these things are great, but you want to start with an immunoglobulin, like the one that you have in your HistaGut IgG product. You want to weed the garden, weed the microbiome garden first, of all the bad guys, then you want to feed it with good glutamine, and probiotics, and enzymes, and things like that.
And that's where people go wrong with gut health. They take a probiotic, they don't realize that their diversity is all out of whack, that their antigen or inflammatory bacterial load is super duper high. And then what happens is that probiotic is sitting there undigested, which then causes die-off, which then they go, I tried probiotics, it kind of made me feel worse. That's called die-off, and that's because there's too many bad guys and not enough good guys. So what we want to do is we want to mobilize all the bad guys and get them out of there. And the way that you do that is with a serum-based IgG called ImmunoLin, like the one that you have in your product.
Jennifer Fugo (37:06.462)
Awesome. Well, thank you so much for sharing all this today.
Brian Kaufman (37:10.046)
My pleasure.
Jennifer Fugo (37:12.07)
I'm sure I will have a lot of questions after this and I would love to have you come back and answer those as well, and maybe we can dive into some more research moving forward. But thank you, I really appreciate it, I love nerding out about this kind of stuff. And I really hope that everybody listening starts to realize we don't have to just do, right, it's not just about fibers, it's not just about probiotics. There's other things that you can do that can have a really substantial impact on supporting a healthy gut microbiome, gut health, and this can be one of them. So thank you.
Brian Kaufman (37:43.456)
Absolutely. Thank you so much for having me on. I would absolutely love to answer questions and come back on again.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
REFERENCES
- Survival and digestibility of orally-administered immunoglobulin preparations containing IgG through the gastrointestinal tract in humans
- ImmunoLin vs Colostrum white paper
- https://www.dovepress.com/serum-derived-bovine-immunoglobulin-protein-isolate-postulated-mechani-peer-reviewed-fulltext-article-CEG
- Bovine Immunoglobulin/Protein Isolate Binds Pro-Inflammatory Bacterial Compounds and Prevents Immune Activation in an Intestinal Co-Culture Model
- antigen binding list
- Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects with Diarrhea-Predominant Irritable Bowel Syndrome
